Despite the name "melanosis," the pigment isn't melanin. The Pigment: It is actually lipofuscin, a "wear and tear" pigment. The Process: Anthraquinone laxatives cause apoptosis (cell death) of the colonic epithelial cells. Pigmented Lesions of the Oral Mucosa: Clinical Presentation, Histology, and Recommendations for Management American Journal of Clinical Dermatology Springer Nature Link Amelanotic Melanoma Pictures Happy Wednesday! , In this video, a patients labial melanotic macule (a benign pigmented lesion) is being treated with liquid nitrogen. Labial melanotic macules are flat and asymmetrical with a Labial melanotic macule. B). Increased numbers of me lanocytes along Download Scientific Diagram