Tylenol And Glutathione Invigor Medical GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Sex differences in glutathione metabolism and acetaminophen toxicity