Acetaminophen metabolism Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Paracetamol (Acetaminophen) and the Developing Brain Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy