Giant Centrifugal and Necrotizing Cutaneous Metastases of Melanoma Nicola di Meo, Katiuscia Nan, Silvia Vichi, Alessandro Gatti, Giusto Trevisan, 2016 Diffuse cutaneous melanosis: rare complication of metastatic melanoma * ScienceOpen After the immune system destroys melanoma tumors, visible melanin can be left behind. We tracked tumoral melanosis in a case series of patients on immunotherapy and offer suggestions for how to monitor What Is Metastatic Melanoma and Where Can It Spread? Melanoma metastasis: new concepts and evolving paradigms Oncogene