Melanosis coli: Symptoms, causes, treatment, and more Pigmented Lesions of the Oral Mucosa: Clinical Presentation, Histology, and Recommendations for Management American Journal of Clinical Dermatology Springer Nature Link Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Differentiating between early melanomas and melanocytic nevi: A state of the art review ScienceDirect Melanoma Skin Cancer