Are Freckles on Lips a Cause for Concern? Causes, Remedies Lip pigmentation Clinical Challenge: Dark Lesion on Lower Lip MPR Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in A collection of resources for RACGP exams Next Gen GP Text Book live webinars AKT and KFP questions
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