Metabolic activation pathway of acetaminophen. Generally, NAPQI is Download Scientific Diagram 5 Oxoprolinuria as a Cause for Metabolic Acidosis Renal Fellow Network Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Mini Review Acetaminophen Toxicity and 5 Oxoproline (Pyroglutamic Acid): A Tale of Two Cycles, One an ATP Depleting Futile Cycle Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which